The Best NMN Supplement in 2023 | Top 5 Brands Reviewed

Longevity has been sought after since the dawn of time.

We used to hunt the jungle searching for the fountain of youth, but now we search the web for the best NMN supplement.

Quite the evolution, and for good reason.

NMN or Nicotinamide Mononucleotide is very powerful.

In this article, I am going to break down what NMN is, what it does, NMN benefits, NMN side effects, the best NMN supplement on the market, and how to use NMN for longevity. And we’re going to support it all with science and studies.

We’ll even throw in some NMN before and after stories.

Okay let’s get into it – while you’re still young..

So, What is NMN?

NMN is a naturally occurring molecule in the body and it plays an important role in cellular energy production.

NMN is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), which is essentially what we are after. The problem is, taking NAD+ directly does not work very well as it is very large and this makes it hard to get into the cells.

So we take precursors to NAD+ instead, like NMN – so these can easily enter the cell and be used to create more NAD+ in the cells (source).

But Why Do We Want More NAD+?

NAD+ is essential for cell functioning and responsible for repairing DNA damage caused by aging. NAD+ also helps convert food into energy, so your cells can keep running like a well-oiled machine.

As we age, we lose more and more NAD+ (source). Increasing NAD+ levels will give you more cellular energy, better mitochondrial function & it activates the sirtuins, which slows down the aging process (source).

I’m not gonna get too geeky here guys, this stuff gets heavy. If you want to go deep I recommend this book or this podcast.

NMN is One of 3 NAD Precursors

NAD has 3 main precursors. They are:

• Vitamin B3 (Niacin)
• NR or Nicotinamide Riboside
• And NMN

So why not just take Vitamin B3 or NR?

You can, but vitamin B3 requires the most chemical reactions to eventually end up as NAD in the body. Supplementing with vitamin B3 may be good, but it won’t result in a measurable increase in NAD. NR is in second place. NR will in fact increase NAD, as shown in many studies, but as Dr. David Sinclair states in this epic podcast, NMN is even better.

NMN has been proven to increase lifespan in rats by 10-15% (Source).

That’s insane, and if translated to humans would mean a 10-15 year increase in lifespan.

But that is yet to be seen, as it would require a 100+ year study to see the results (the biggest challenge of anti-aging research). That’s why most studies are performed on rats or fruit flies with a much shorter lifespans.

But what we do know, is that NMN will increase your NAD levels by 2-3 fold as Dr. Sinclair has demonstrated in his lab. And this can happen relatively quickly just by supplementing NMN.

These 2 studies done in 2022 support the claims that NMN absolutely will increase your NAD levels.

• Igarashi, M. et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. npj aging 8, (2022)
• Okabe, K. et al. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Front Nutr 9, (2022)

So we know without a doubt that supplementing with NMN will increase our NAD levels, which is why I take it every day and have created this list of the best NMN supplements (in my opinion), so you can do the same.

Now – let’s go a little deeper into NMN.

What Are The Benefits of Taking NMN?

The biggest NMN benefit is its ability to slow down the aging process and protect cells from damage caused by aging. It does this by promoting healthy mitochondrial function, increasing energy production and protecting against cellular oxidation caused by free radicals (source).

Additionally, it has been shown to improve cognitive function, reduce inflammation, and even combat obesity. All of these benefits are backed by science and studies.

To see them all check out this resource we reference here.

But just to summarize, the main benefits of NMN are:

– Lengthening Lifespan

– Restoring Mitochondrial Activity

– Increasing NAD levels

– Enhancing Insulin Sensitivity

– Protects Against Heart Disease

– Increases Cellular Energy Metabolism

– Suppress Age-Related Weight Gain

– Supports Your DNA Repair

– Enhanced Physiologic Resilience

– Improved Muscle Endurance

Again, all of these are backed by science and studies. To learn more about each of the benefits of NMN named here and some that we didn’t mention, check out this article.

What is The Best NMN Supplement?

Okay guys and gals. So what is the best NMN supplement on the market? Let’s dive into this head first. To start, let me share my criteria for suggesting the top picks.

Again, I’ve used NAD for over a year, and have tried many of these brands. I also read and research other real users of each brand to get an overall insight to which ones are delivering the best results. Here’s what I look for:

So what are the best NMN supplements? Here we go.

#1: WONDER:FEEL With Activated NMN (Youngr)

WINNER!

WONDER:FEEL

NMN Dosage: 900mg

Flavors: A powerful dosage of pure NMN, with extremely high quality supporting ingredient and an average price point puts wonder:feel at #1. Read the full review below.

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Wonderfeel is a supplement I really like. Wonderfeel is a leading biosciences company out of San Francisco which offers the most potent NAD precursor formula featuring a 900mg NMN dose that is backed by the latest clinical trials. 

Now, Wonderfeel is not liposomal, which is the most optimal form for absoption based on my research – but the latest clinical trials show that a 900mg dose of NMN provided users with the most health benefits / health scores increases based on SF36 – Median Values as seen in the chart below. Plus, most liposomal forms only contain around 250mg of NMN, so I think it evens out.

Engineered by Andrew Salzman, a prominent Harvard MD, professor, and scientist with over 50 patents and nearly 30 years of expertise in NAD and cellular health, the patented Wonderfeel formula features unique ingredients, including Ergo from mushrooms, and hydroxytyrosol from olive fruit and resveratrol, plus 100% of your daily Vitamin d3.

The high dosage of NMN and the fact that they pair it with resveratrol is why Wonderfeel got my number 1 pick as the best NMN supplement on the market right now. I’ve got it right here in my hand as I write this article.

But why resveratrol you ask?

Basically, studies have shown that when pairing NMN with resveratrol you get a 1.7X higher increase in overall NAD levels in the blood. This means that a supplement containing resveratrol will likely be 1.7X more potent than one without. This is a crucial factor to why I ranked Wonderfeel as the best overall NMN supplement.

If you want to learn more about why pairing NMN and Resveratrol is such a potent combo for anti-aging then check out this short article I wrote here.

So overall, Wonderfeel is a solid product and I love the way it makes me feel. It’s got my number 1 pick as the best NMN supplement – but #2 is a very close second and worth considering.

#2: Renue By Science – Lipo NAD⁺ Complete – NAD⁺, NMN, & NR

Lipo NAD+ Complete

NMN Dosage: 250mg Per Serving

The dosage of NMN may not be high, but this NMN supplement is paired with NR & NAD+ in its whole form and has proven results from many users.

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Renue By Science is a really amazing company.

They have a lot of NMN supplements, but I think their best NMN supplement is Lipo NAD⁺ Complete – because it contains NMN, NR and NAD+ itself.

Plus, it’s in liposomal form – so the absorption is going to be excellent.

And this stuff works.

Holly from Life & DIY (a badass Youtuber) did extensive measuring of her NAD levels over time (respect) and she found that before starting on Lipo NAD+ her NAD levels were 25.8. After taking it for 2 months they were 44. Wow!

Now, let’s talk about the pros and cons of this supplement.

Pros:

• Contains a powerful trio of NAD⁺, NMN, and NR, which are all known to support healthy aging and energy metabolism.
• Formulated with liposomal delivery technology for better absorption and bioavailability.

Cons:

• On the pricier side compared to other supplements on the market.
• Contains a proprietary blend, which means we don’t know the exact amounts of each ingredient in the supplement.

Overall, I’d say Renue By Science’s Lipo NAD⁺ Complete is a solid choice for anyone looking for a high-quality NMN supplement. The addition of NAD⁺ and NR make it a well-rounded supplement for supporting healthy aging and energy metabolism, and the liposomal delivery technology ensures better absorption and bioavailability. The only downside is the price really. And I would like to see resveratrol in there.

However, if you’re looking for the best NMN supplement on the market, this is one this is definitely worth considering, and it will most definitely boost your NAD levels.

#3: Hello100 Liposomal NMN+

Hello100

NMN Dosage: 200mg Per Serving

A really solid NMN supplement, containing both NMN and resveratrol as well as being in a liposomal form. This is a solid option for anyone with a lower budget, as with our 50% off coupon code menprovement – the price is quite low.

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When looking for the best NMN supplement, one of the most important thing is to focus on absorption. That’s why I like Hello100, since they prioritze that.

Since NMN is quite a large molecule, it has difficulty getting into the cells. Also, NMN taken in oral form faces harsh conditions in gastrointestinal tract thus reducing supplement stability and bioavailability. So it may not even reach the bloodstream.

Because of this, taking NMN powder, regardless of how pure, may not be the best option unless the dosage is high like in Wonderfeel. This is a really good option and it’s hard to have it in the #3 spot. It could easily be #1 or #2 on this list. So if your budget is lower, go for Hello100.

Like I said before – I used Hello100 for a few months. I have it right here next to me as you can see in the picture of me writing this article. And it’s solid.

Because I like the product I got in touch with the company who makes it and I got you 50% off with the code menprovement. I get a small commission if you use my code – but I only recommend products I would take myself.

Hello100 comes in a pill, which uses liposomal technology and other active ingredients like Betaine (also known as TMG) to further increase the bioavailability.

The liposomes increase cellular uptake drastically improving delivery. It bonds to the cell membranes and releases its active ingredients to the cell for delivery. The NMN is also shielded to pass the highly acidic environment in the gastrointestinal tract.

Does this mean that Hello100 is the best NMN supplement out there? I don’t know. I have not tried them all. But I like the way this makes me feel and the science is solid. I feel very comfortable recommending it to you. The only reason it’s not #1 is dues to the 200mg dose of NAD precursors as opposed to 250 mg NMN/250mg NR in Renue By Science and 900 mg NMN in Wonderfeel.

But, it also contains 5 other synergistic ingredients, like Resveratrol which is another positive.

Quick Detour: More on NMN And Resveratrol

I’ve spoken twice about resveratrol in this article so let’s dive a little bit deeper into it before we go onto the 4th best NMN supplement.

I’ve been on a huge resveratrol kick since learning about it last month.

It’s one of my absolute favorite supplements right now & NMN and resveratrol play very well together.

NMN and Resveratrol are both anti-aging compounds that have been studied for their effects on longevity and health. The combination of these two molecules has been shown to be even more effective than either one alone in promoting optimal health and longer life span.

Resveratrol is an antioxidant found in red wine, grapes, and some nuts. It helps reduce inflammation, protect cells from damage caused by free radicals, and improve overall metabolic function. And as you know by now, NMN works to repair damaged cells, optimize energy production, and enhance mitochondrial health.

Together they can help increase cellular energy production, reduce oxidative stress levels, protect against age-related diseases such as Alzheimer’s and cancer, promote healthy aging processes like DNA repair, and improve cognitive health.

If you are looking for a safe and effective way to slow down the aging process and increase your longevity, consider trying a combination of NMN and Resveratrol supplements. Or take one that contains both, as many of the best NMN supplements do.

Learn more about Resveratrol and its effects on cardiovascular health

NAD and Resveratrol: Study reveals taking NMN and Resveratrol can increase NAD+ levels 1.7X more vs taking NMN alone

#4: Do Not Age, Pure NMN Powder

Do Not Age

NMN Dosage: 1,000mg Per Serving

The super high dosage of pure NMN in powder form. Great for anyone who like to mix their supplements with water or juice.

Check The Latest Price

Do not age made the list, not only because of it’s badass name. It’s different from most NMN supplements as it comes in a powder form – which is great for anyone who likes to mix their supplements in smoothies and stuff.

Do I think it’s the best NMN supplement?

While I think it’s solid, and will definitely boost your NAD levels – I think it’s lacking supporting ingredients and some sort of delivery system that stops you from peeing most of it out.

However it made the list because some people like powdered forms, and the dosage is higher than all the others which I think makes up for the fact that some may not end up in the cells as well as some of the others.

#5: The Best (Inexpensive) NMN Supplement – Novos

Novos Boost

NMN Dosage: 250mg Per Serving

The least expensive NMN supplement on this list by far. Yet it’s still really awesome…

Check The Latest Price

Novos Boost is sitting in the fifth spot, but honestly..it could be higher. Let’s call this spot the least expensive spot, because Novos Boost brings a lot for the table – and at $32 a monthly bottle it doesn’t ask a lot in return.

A lot of the picks here are $70+ per month, which is no small ask.

Novos start’s at $44.00 for a single month, but with a subscription it goes as low as $32.00.

Now if you are on a budget, I do recommend Hello100 over Novos. With our coupon code it will run you $39.50 a bottle. It’s a bit better than Novos, because it is liposomal and also contains resveratrol.

But if you want to save even more money, and still support your NAD levels – go for a yearly subscription of Novos. It may not deliver AS much, but if you use it for a year or more then it will help you increase your NAD levels for sure.

How To Use NMN For Longevity

First things first, even the best NMN supplement should be taken as directed by your functional medicine doctor or nutritionist.

Most experts recommend taking 500 – 1000mg per day, split into two doses, but if you’re taking a liposomal form you only need 250mg because the absorption is superior.

When liposomal, it is best taken on an empty stomach to maximize absorption. If not, I recommend taking it with a fatty meal or just follow the recommendation on the bottle.

Taking NMN supplements in combination with healthy lifestyle habits such as eating a nutritious diet, getting enough sleep and exercise, and avoiding excessive stress can help you achieve optimal health and longevity.

So take it every day.

You should start to feel results within 9 days. And for longevity you just keep taking it over the course of years to keep your NAD levels at peak.

It seems daunting to say “hey I’m gonna take this supplement for the next 100 years,” but that’s what would theoretically allow you to slow aging throughout your life to the point that you feel like a healthy 70 year old at age 100.

That’s what it’s mostly about for me. It’s not about just living longer. It’s about slowing aging – so you can feel young, healthy and fit for as long as possible. Well into your hundreds.

Real NMN Reviews

I have been using NMN for the last year and I love it.

I have more energy, more mental clarity, I can run longer and it feels easier, I have a strong sense of well being & I don’t need to sleep as much.

I also notice that I don’t get hungover like I used to & I am just more resilient to stressors in general.

Some other people have said:

“I’ve been using the Liposomal NMN+ for about 30 days now and I can certainly tell that I’m taking it. I work out regularly and eat for performance, I can tell that my fat loss has improved during this time. I’m highly impressed with this product and would absolutely recommend it to my clients for safe energy and an overall well-rounded product!”

– Jonathan Gehrig

“Since I started taking NMN+ I find that I am sleeping better and have more energy in the morning to get a jump start on my day. Throughout the day my mind is clear and calm even when stress arises. I don’t have mid-day crashes and I’m less likely to look for that afternoon sugar boost. I feel physically stronger and have the endurance I need to get through my busy day and then some.”

– Thomas Hale

NMN Before And After Stories

There are many inspiring stories from people who have used NMN for anti-aging purposes. The best NMN supplement will do this.

Many of them experienced an increase in energy levels, improved mental clarity, better skin tone, increased muscle mass and strength, reduced inflammation and even weight loss!

These stories show that taking NMN can make a significant difference to your overall health and well-being.

But what are the numbers?

The one thing I didn’t do which I would have loved to was measure my NAD levels before and after taking NMN.

Luckily, many other people have so I will piggyback off of their results.

Holly, a badass Youtuber, did do extensive measuring of her NAD levels over time (respect) and she found that before starting on an NMN + NR supplement for 2 months her NAD levels were 25.8. After the 2 months they were 44.

Impressive gains.

NMN Dosage

The recommended dosage for NMN is 500 – 1000mg per day in powder/pill form, split into two doses. But remember, the powder form is not absorbed very well, so opt for a liposomal form. When taking a liposomal form, dosages as small as 200mg can be more effective than 500 mgs of powder due to increased absorption.

Remember, you should always speak with your doctor before taking any supplement and follow their instructions closely.

Does NMN Have Any Side Effects?

NMN is considered safe to take in recommended dosage as it is naturally occurring in the body.

Most people experience no side effects at all.

That being said, I would not exceed the recommended dosage as this could cause some negative effects in your body, as would anything.

People taking higher doses of NMN may experience some digestive issues such as bloating, nausea and diarrhea. It is also not recommended for people on certain medications such as anticoagulants.

To be safe, consult your doctor before use.

Does NMN Cause Cancer?

I absolutely don’t mean to scare you, but it must be said – always consult your doctor before trying NMN or any NAD boosting supplement.

While boosting NAD increases lifespan in general, there is one study where rats with a specific gene that predisposed them to Pancreatic Cancer were given NAD & those rats with that gene experienced an acceleration of Cancer cell growth.

Do I think NAD causes Cancer? No. But if you have that gene that predisposes you to certain types of Cancer (I don’t know 100% which gene it is – learn more here), then you wouldn’t want to boost your NAD, and NMN would do just that.

So in that rare case I would avoid it.

But boosting NAD in general has been shown over and over to decrease all cause mortality and to prolong life, so I feel 100% confident in increasing my NAD levels as do millions of other people. It makes me feel amazing.

Plus there are many studies that suggest raising NAD would have anticancer effects:

NMN FAQ’s

Here’s a few commonly asked questions when it comes to using NMN.

– What is the best time to take NMN?

From what I have gathered, it is best to take liposomal NMN on an empty stomach in order to maximize absorption. However many brands I have used that are not liposomal say to take it with a fatty meal to increase the uptake.

This goes for even the best NMN supplement.

– Is NMN safe?

Yes, NMN is generally considered safe when taken as directed by your doctor or nutritionist. However, people taking higher doses of NMN may experience some digestive issues such as bloating, nausea and diarrhea. It is also not recommended for people on certain medications such as anticoagulants.

– Can I combine NMN and Resveratrol?

Yes, combining NMN and Resveratrol can be beneficial for promoting optimal health and longevity. The combination of these two molecules has been shown to be even more effective than either one alone in slowing down the aging process and reducing the risk of age-related diseases.

– How long does it take for NMN to work?

The effects of NMN can be felt within a few days or weeks, depending on the individual’s metabolism and lifestyle habits. However, for maximum benefits it is best to take NMN regularly over a period of several months to see meaningful results.

– What is the max NMN dosage?

The maximum recommended daily dose of NMN is 1000 milligrams in powder/pill form. However, it is important to consult with your doctor or nutritionist before taking any supplement to determine the appropriate dosage for you individually. Taking higher doses may result in digestive issues such as bloating and diarrhea, so always follow the advice of an expert when considering supplementation. Additionally, remember that even the best NMN supplement should be taken in combination with other healthy lifestyle habits such as eating a balanced diet and exercising regularly for optimal results!

– Should I take NMN on an empty stomach or with food?

Follow the instructions on your bottle as not all NMN is created with the same delivery mechanism.

– How effective is the best NMN supplement?

NMN is so effective that big pharma are trying to get it banned as a supplement so they can make it a prescription and make billions of dollars off it’s miraculous effects.

True story:

Conclusion

NMN is an exciting supplement with potential anti-aging benefits that can help promote healthier and longer life when taken correctly. It is important to consult with your doctor or nutritionist before taking any supplement and follow their instructions closely. Additionally, it is essential to take NMN consistently over a period of several months and in combination with other healthy lifestyle habits such as eating a balanced diet and exercising regularly for optimal results.

Taking NMN alone will not stop the aging process! However, when combined with these healthy practices it can help you achieve healthier and longer life.

I think any of the products I listed above are a great fit. It just depends on you. If you’re on a budget, go with Hello100. If not – go with Wonderfeel. This is my ultimate recommendation, but honestly any of these will work and they are all great brands.

Thanks for reading guys. Let us know in the comments below what you think the best NMN supplement is & what (if any) benefits you got from taking an NMN supplement.

Sean Russell, Life Coach

Hey guys, I’m Sean a self improvement enthusiast with over 10 years experience in the health and wellness industry. My mission is to help you become the best version of yourself.

Certifications: Certified Life Coach, Dating Coach, Nutritionist